Caregivers' experiences with the new family‐centred paediatric physiotherapy programme COPCA : a qualitative study

Caregivers' experiences during early intervention of their infant with special needs have consequences for their participation in the intervention. Hence, it is vital to understand caregivers' view. This study explored caregivers' experiences with the family-centred early intervention programme "COPing with and CAring for infants with special needs" (COPCA)

An XML Query Engine for Network-Bound Data

XML has become the lingua franca for data exchange and integration across administrative and enterprise boundaries. Nearly all data providers are adding XML import or export capabilities, and standard XML Schemas and DTDs are being promoted for all types of data sharing. The ubiquity of XML has removed one of the major obstacles to integrating data from widely disparate sources –- namely, the heterogeneity of data formats. However, general-purpose integration of data across the wide area also requires a query processor that can query data sources on demand, receive streamed XML data from them, and combine and restructure the data into new XML output -- while providing good performance for both batch-oriented and ad-hoc, interactive queries. This is the goal of the Tukwila data integration system, the first system that focuses on network-bound, dynamic XML data sources. In contrast to previous approaches, which must read, parse, and often store entire XML objects before querying them, Tukwila can return query results even as the data is streaming into the system. Tukwila is built with a new system architecture that extends adaptive query processing and relational-engine techniques into the XML realm, as facilitated by a pair of operators that incrementally evaluate a query’s input path expressions as data is read. In this paper, we describe the Tukwila architecture and its novel aspects, and we experimentally demonstrate that Tukwila provides better overall query performance and faster initial answers than existing systems, and has excellent scalability

Oscillons: an encounter with dynamical chaos in 1953?

We present evidences that Ben F. Laposky (1914-2000) might have been the first person who created a family of nonlinear analog circuits that allowed him to observe chaotic attractors and other trademarks of nonlinear science as early as 1953.Comment: accepted to Chao

Piazza: Data Management Infrastructure for Semantic Web Applications

The Semantic Web envisions a World Wide Web in which data is described with rich semantics and applications can pose complex queries. To this point, researchers have defined new languages for specifying meanings for concepts and developed techniques for reasoning about them, using RDF as the data model. To flourish, the Semantic Web needs to be able to accommodate the huge amounts of existing data and the applications operating on them. To achieve this, we are faced with two problems. First, most of the world\u27s data is available not in RDF but in XML; XML and the applications consuming it rely not only on the domain structure of the data, but also on its document structure. Hence, to provide interoperability between such sources, we must map between both their domain structures and their document structures. Second, data management practitioners often prefer to exchange data through local point-to-point data translations, rather than mapping to common mediated schemas or ontologies. This paper describes the Piazza system, which addresses these challenges. Piazza offers a language for mediating between data sources on the Semantic Web, which maps both the domain structure and document structure. Piazza also enables interoperation of XML data with RDF data that is accompanied by rich OWL ontologies. Mappings in Piazza are provided at a local scale between small sets of nodes, and our query answering algorithm is able to chain sets mappings together to obtain relevant data from across the Piazza network. We also describe an implemented scenario in Piazza and the lessons we learned from it

Febuxostat, an Inhibitor of Xanthine Oxidase, Suppresses Lipopolysaccharide-Induced MCP-1 Production via MAPK Phosphatase-1-Mediated Inactivation of JNK.

Excess reactive oxygen species (ROS) formation can trigger various pathological conditions such as inflammation, in which xanthine oxidase (XO) is one major enzymatic source of ROS. Although XO has been reported to play essential roles in inflammatory conditions, the molecular mechanisms underlying the involvement of XO in inflammatory pathways remain unclear. Febuxostat, a selective and potent inhibitor of XO, effectively inhibits not only the generation of uric acid but also the formation of ROS. In this study, therefore, we examined the effects of febuxostat on lipopolysaccharide (LPS)-mediated inflammatory responses. Here we show that febuxostat suppresses LPS-induced MCP-1 production and mRNA expression via activating MAPK phosphatase-1 (MKP-1) which, in turn, leads to dephosphorylation and inactivation of JNK in macrophages. Moreover, these effects of febuxostat are mediated by inhibiting XO-mediated intracellular ROS production. Taken together, our data suggest that XO mediates LPS-induced phosphorylation of JNK through ROS production and MKP-1 inactivation, leading to MCP-1 production in macrophages. These studies may bring new insights into the novel role of XO in regulating inflammatory process through MAPK phosphatase, and demonstrate the potential use of XO inhibitor in modulating the inflammatory processes

Neurotrophic Factors NGF, GDNF and NTN Selectively Modulate HSV1 and HSV2 Lytic Infection and Reactivation in Primary Adult Sensory and Autonomic Neurons

Herpes simplex viruses (HSV1 and HSV2) establish latency in peripheral ganglia after ocular or genital infection, and can reactivate to produce different patterns and frequencies of recurrent disease. Previous studies showed that nerve growth factor (NGF) maintains HSV1 latency in embryonic sympathetic and sensory neurons. However, adult sensory neurons are no longer dependent on NGF for survival, some populations cease expression of NGF receptors postnatally, and the viruses preferentially establish latency in different populations of sensory neurons responsive to other neurotrophic factors (NTFs). Thus, NGF may not maintain latency in adult sensory neurons. To identify NTFs important for maintaining HSV1 and HSV2 latency in adult neurons, we investigated acute and latently-infected primary adult sensory trigeminal (TG) and sympathetic superior cervical ganglia (SCG) after NTF removal. NGF and glial cell line-derived neurotrophic factor (GDNF) deprivation induced HSV1 reactivation in adult sympathetic neurons. In adult sensory neurons, however, neurturin (NTN) and GDNF deprivation induced HSV1 and HSV2 reactivation, respectively, while NGF deprivation had no effects. Furthermore, HSV1 and HSV2 preferentially reactivated from neurons expressing GFRα2 and GFRα1, the high affinity receptors for NTN and GDNF, respectively. Thus, NTN and GDNF play a critical role in selective maintenance of HSV1 and HSV2 latency in primary adult sensory neurons

Schema Mediation for Large-Scale Semantic Data Sharing

Intuitively, data management and data integration tools should be well suited for exchanging information in a semantically meaningful way. Unfortunately, they suffer from two significant problems: they typically require a common and comprehensive schema design before they can be used to store or share information, and they are difficult to extend because schema evolution is heavyweight and may break backward compatibility. As a result, many large-scale data sharing tasks are more easily facilitated by non-database-oriented tools that have little support for semantics. The goal of the peer data management system (PDMS) is to address this need: we propose the use of a decentralized, easily extensible data management architecture in which any user can contribute new data, schema information, or even mappings between other peers schemas. PDMSs represent a natural step beyond data integration systems, replacing their single logical schema with an interlinked collection of semantic mappings between peers individual schemas. This paper considers the problem of schema mediation in a PDMS. Our first contribution is a flexible language for mediating between peer schemas that extends known data integration formalisms to our more complex architecture. We precisely characterize the complexity of query answering for our language. Next, we describe a reformulation algorithm for our language that generalizes both global-as-view and local-as-view query answering algorithms. Then we describe several methods for optimizing the reformulation algorithm and an initial set of experiments studying its performance. Finally, we define and consider several global problems in managing semantic mappings in a PDMS

Correcting for optical aberrations using multilayer displays

Optical aberrations of the human eye are currently corrected using eyeglasses, contact lenses, or surgery. We describe a fourth option: modifying the composition of displayed content such that the perceived image appears in focus, after passing through an eye with known optical defects. Prior approaches synthesize pre-filtered images by deconvolving the content by the point spread function of the aberrated eye. Such methods have not led to practical applications, due to severely reduced contrast and ringing artifacts. We address these limitations by introducing multilayer pre-filtering, implemented using stacks of semi-transparent, light-emitting layers. By optimizing the layer positions and the partition of spatial frequencies between layers, contrast is improved and ringing artifacts are eliminated. We assess design constraints for multilayer displays; autostereoscopic light field displays are identified as a preferred, thin form factor architecture, allowing synthetic layers to be displaced in response to viewer movement and refractive errors. We assess the benefits of multilayer pre-filtering versus prior light field pre-distortion methods, showing pre-filtering works within the constraints of current display resolutions. We conclude by analyzing benefits and limitations using a prototype multilayer LCD.National Science Foundation (U.S.) (Grant IIS-1116452)Alfred P. Sloan Foundation (Research Fellowship)United States. Defense Advanced Research Projects Agency (Young Faculty Award)Vodafone (Firm) (Wireless Innovation Award

Concept and optical design of the cross-disperser module for CRIRES

This is the peer reviewed version of the following article: Oliva, Ernesto, A. Tozzi, D. Ferruzzi, L. Origlia, A. Hatzes, R. Follert, T. Loewinger et al. "Concept and optical design of the cross-disperser module for CRIRES+." In SPIE Astronomical Telescopes+ Instrumentation, pp. 91477R-91477R. International Society for Optics and Photonics, 2014, which has been published in final form at 10.1117/12.2054381

Distributed abstraction and verification of an installed optical fibre network.

The management of wavelength routed optical mesh networks is complex with many potential light path routes and numerous physical layer impairments to transmission performance. This complexity can be reduced by applying the ideas of abstraction from computer science where different equipment is described in the same basic terms. The noise-to-signal ratio can be used as a metric to describe the quality of transmission performance of a signal propagated through a network element and accumulates additively through a sequence of such elements allowing the estimation of end-to-end performance. This study aims to explore the robustness of the noise-to-signal ratio metric in an installed fibre infrastructure. We show that the abstracted noise-to-signal ratio is independent of the observers and their location. We confirm that the abstracted noise-to-signal ratio can reasonably predict the performance of light-paths subsequently set in our network. Having a robust network element abstraction that can be incorporated into routeing engines allows the network management controller to make decisions on the most effective way to use the network resources in terms of the routeing and data coding format